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@ZdenekVrozina "COVID didnt end - it changed the baseline of how often people fall ill miss work and drop out of the labor force. A new JAMA study shows the US now lives in a permanent flu-season mode all year round🧵"
X Link @ZdenekVrozina 2025-10-10T21:21Z 7736 followers, 103.1K engagements

"Well worth reading"
X Link @ZdenekVrozina 2025-10-16T14:43Z 7736 followers, 37.4K engagements

"Since 2022 weve seen a sharp rise in most types of cancer among working-age adults in England. The data dont yet tell us why - but the trend is clear. If confirmed this could turn out to be one of the most serious public health failures in modern history. @szupraha @ZdravkoOnline @adamvojtech86"
X Link @ZdenekVrozina 2025-10-06T21:30Z 7723 followers, 19.7K engagements

"Yes we wrote about this study. It is important. A study from Cambridge in Brain shows that even months after COVID-19 survivors still carry measurable inflammation-related changes in the brainstem - the part of the brain that keeps you breathing awake and alive🧵"
X Link @ZdenekVrozina 2025-10-09T08:24Z 7715 followers, 12K engagements

"SARS-CoV-2 carries proteins designed to manipulate immune signaling inside the brain. Several of them target the same pathways that keep microglia and neurons in balance. Together these proteins dont just infect cells - they reprogram innate immunity inside the nervous system"
X Link @ZdenekVrozina 2025-10-09T08:24Z 7718 followers, XXX engagements

"The authors (Salamon Pretorius Ewing Bar-Yam and others) review a large body of evidence. Their conclusion - SARS-CoV-2 is not HIV - but it shares key biological traits with it - immune exhaustion viral persistence and systemic inflammation"
X Link @ZdenekVrozina 2025-10-14T19:36Z 7713 followers, XXX engagements

"Unlike HIV SARS-CoV-2 spreads through the air infects repeatedly and leaves a cumulative immune toll on the population. Reinfections are not harmless - they may compound immune and neurological damage over time"
X Link @ZdenekVrozina 2025-10-14T19:36Z 7714 followers, XXX engagements

"In a mouse model of EBV-related cancer V1 cells migrated straight into the tumor became activated and slowed tumor growth. Not a cure yet - but a clear biological signal that this immune pathway could be harnessed therapeutically"
X Link @ZdenekVrozina 2025-10-15T18:44Z 7721 followers, XXX engagements

"Meanwhile increased RD in the right amygdala may signal microstructural stress - poorer myelin integrity and disrupted emotional processing. So structural change on both sides but in different directions"
X Link @ZdenekVrozina 2025-10-18T13:41Z 7736 followers, XXX engagements

"The longer the smell loss lasted the stronger the DTI changes - especially in the amygdala and piriform cortex. That points to ongoing remodeling not a static injury"
X Link @ZdenekVrozina 2025-10-18T13:41Z 7736 followers, XXX engagements

"And thats where the parallels emerge: HIV EBV CMV - all use similar tricks to hide persist and exhaust. SARS-CoV-2 seems to have learned the same playbook"
X Link @ZdenekVrozina 2025-10-09T08:24Z 7727 followers, XXX engagements

"Its a warning sign that SARS-CoV-2 can disrupt brain balance in a way that closely resembles early neurodegenerative changes. That doesnt mean everyone will develop dementia - but it suggests the brain may enter a similar trajectory of inflammation and stress if these processes arent stabilized"
X Link @ZdenekVrozina 2025-10-10T15:12Z 7732 followers, XXX engagements

"@ClubEffective @mdkatrsk Good catch. The data come from the same MGH pediatric cohort previously analyzed by the Walt lab using Simoa. That assay detects full-length viral spike confirming infection-derived antigenemia rather than a vaccine source"
X Link @ZdenekVrozina 2025-10-12T16:40Z 7726 followers, XX engagements

"Biological consequences. This long-term shutdown of the repair program can cause chronic fatigue and poor microcirculation increase the risk of microclots and vascular aging and potentially underlie Long COVID itself"
X Link @ZdenekVrozina 2025-10-13T14:03Z 7729 followers, 2407 engagements

"These patients were infected with early variants (Wuhan/Alpha) - the ones with a strong affinity for blood vessel cells. But the mechanism - the switching off of KLF2eNOS signaling - could still happen with newer variants just more quietly"
X Link @ZdenekVrozina 2025-10-13T14:03Z 7727 followers, 2208 engagements

"Why it matters. EBV is linked to certain cancers and autoimmune diseases. V1 T cells could offer a new way to target infected or malignant cells that evade classical immune recognition - and they could be made off the shelf usable for any patient"
X Link @ZdenekVrozina 2025-10-15T18:44Z 7724 followers, XXX engagements

"Sum: EBV control = cellular immunity not antibodies. V1 T cells kill infected cells without HLA. A new path toward broad universal cell-based therapies"
X Link @ZdenekVrozina 2025-10-15T18:44Z 7726 followers, XXX engagements

"Jimnes at al. A high-resolution unbiased analysis of the cellular immune response to Epstein-Barr virus"
X Link @ZdenekVrozina 2025-10-15T18:44Z 7726 followers, XXX engagements

"@MDinCanada @BalancedBM SARS2 infection didnt affect gonadal hormones. Infected females showed prolonged corticosterone elevation but their estrogen and testosterone levels stayed unchanged"
X Link @ZdenekVrozina 2025-10-16T17:14Z 7725 followers, XX engagements

"@BalancedBM @MDinCanada Absolutely - serum isnt the best proxy this study focused on X-linked immune regulation mainly not on steroid metabolism or conversion"
X Link @ZdenekVrozina 2025-10-16T17:34Z 7725 followers, XX engagements

"Baik at al. Discovery of molecular signature of long-term psychiatric sequelae in COVID-19 through proteome profiling of dried blood spots"
X Link @ZdenekVrozina 2025-10-10T15:12Z 7732 followers, XXX engagements

"Possibly one of the most important studies on EBV and human immunity in a long time. It shows that a special type of immune cell - T cells (V1) - can detect and destroy EBV-infected cells even when the virus hides from the classical immune system.🧵"
X Link @ZdenekVrozina 2025-10-15T18:44Z 7734 followers, 8584 engagements

"Thats why women are more likely to experience long COVID symptoms that look autoimmune - persistent inflammation exhausted T cells (PD-1+ CTLA-4+ LAG-3+) and low-grade neuroinflammation without viral persistence. The virus leaves - but the immune activation stays"
X Link @ZdenekVrozina 2025-10-15T19:48Z 7736 followers, 4674 engagements

"In other words. SARS-CoV-2 doesnt just trigger a transient immune response - it epigenetically reprograms X-linked genes. This may cause long-term immune dysregulation even in previously healthy women"
X Link @ZdenekVrozina 2025-10-15T19:48Z 7735 followers, 5201 engagements

"@cfs_research I get your frustration. The signal is there just not replicated robustly mostly because of small samples and variability in TSPO binding ligand affinity PET correction methods"
X Link @ZdenekVrozina 2025-10-16T20:03Z 7735 followers, XX engagements

"New preprint from Harvard & Massachusetts General Hospital -children with Long COVID show markedly increased levels of fibrinaloid microclots in their blood The highest levels appear in those with persistent SARS-CoV-2 spike protein in circulation🧵"
X Link @ZdenekVrozina 2025-10-11T17:37Z 7735 followers, 40.6K engagements

"COVID-19 doesnt just cause inflammation. It switches off the genes that repair blood vessels - and switches on those that drive inflammation and destruction. And whats worse - this state lasts for at least six months long after the infection is gone🧵"
X Link @ZdenekVrozina 2025-10-13T14:03Z 7736 followers, 149.3K engagements

"SARS-CoV-2 doesnt produce a classic toxin. But it reprograms our lipid metabolism so deeply that the cell enters a toxic pro-inflammatory oxidative state. Functionally it behaves like a toxin-like infection🧵"
X Link @ZdenekVrozina 2025-10-14T13:39Z 7736 followers, 15.2K engagements

"A previous study had already shown volume loss in the amygdala and hippocampus among people with long-term post-COVID smell loss - evidence of limbic atrophy. Horwitz et al. JAMA Otolaryngology 2025"
X Link @ZdenekVrozina 2025-10-18T13:52Z 7736 followers, XXX engagements

"This new Scientif Rep data add another layer subtle microstructural remodeling - suggesting that even after tissue loss the brain keeps trying to reorganize its emotionalolfactory network"
X Link @ZdenekVrozina 2025-10-18T13:55Z 7736 followers, XXX engagements