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@nc_znc ". a X OOM increase in recording bandwidth since 2008. However this comes with persistent tradeoffs between coverage temporal resolution recording duration and invasiveness and whole-brain single-cell single-spike res recordings are still beyond the field's grasp. 4/N"
X Link @nc_znc 2025-10-28T21:52Z 1030 followers, XXX engagements

"Connectomics advanced from the seminal C. elegans connectome to full insect and larval fish brains. AI has cut neuron reconstruction costs by X OOMs and new imaging methods are adding molecular annotations moving the field beyond the "naked" wiring diagrams of the past. 5/N"
X Link @nc_znc 2025-10-28T21:52Z 1030 followers, XXX engagements

"However reconstructed connectomes so far are "naked" lacking the molecular detail necessary to predict function. Further new challenges emerge at mammalian scale: imaging becomes a hurdle proofreading remains a cost-driver and data starts to reach exabyte scale. 6/N"
X Link @nc_znc 2025-10-28T21:52Z 1031 followers, XXX engagements

"Modeling is also advancing. Connectome-constrained models reproduce simple behaviors in both C. elegans and the fly and the shift from CPUs to GPUs coupled with new frameworks enabled feasibility studies at human scale. Further emulation benchmarks are now emerging. 7/N"
X Link @nc_znc 2025-10-28T21:52Z 1031 followers, XXX engagements