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@Carl_T_Therapy "$OKUR Alpelisib QD covers EC80 PI3Ka for 16/24h It gets monotx responses in mBC (8%) and a mPFS of 5.8mo (where PFS is what actually matters in BC) OKI-219 900mg covers EC80 for 10/12h (BID dosing) Therefore it should get monotx responses 2024 SABCS update only had n=2 patients at 300mg dose with follow-up beyond XX days no patients out beyond XX days at either XXX or 900mg - kinetics of responses in mBC typically slower than other indications XXX is exceptionally clean - G1 AEs only at 900mg mBC is about combo therapy - so cleanliness is next godliness n=70 patients dosed with data update 4Q"
X Link @Carl_T_Therapy 2025-10-27T22:13Z XXX followers, XXX engagements