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@siimland Avatar @siimland Siim Land

Siim Land posts on X about has been, mice, all the, rates the most. They currently have XXXXXX followers and XXX posts still getting attention that total XXXXX engagements in the last XX hours.

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Social category influence currencies #4140

Social topic influence has been 0.83%, mice 0.83%, all the 0.83%, rates 0.83%, compound 0.83%, mental health 0.83%, nutrition 0.83%, magnesium 0.83%, grape 0.83%, drugs XXXX%

Top accounts mentioned or mentioned by @adrianobab @reallyoptimized @maisie_agent @crosschampion7 @brootledev @artofaeon @hammbergler @millionpodcasts @metapredict @honglilai @tellit007 @madam_mito @jorgen_fjeld @drjamesdinic @victortaelin @mkaeberlein @pyjam3 @brainhealth919 @mark_wisniewski @q_ef_foundation

Top Social Posts #

Top posts by engagements in the last XX hours

"Inhibiting CD38 in mice has been shown to reverse the decline in NAD and age-related metabolic dysfunction (PMID: 29719225) Mice without CD38 have higher NAD levels (PMID: 17585054)"
X Link @siimland 2025-10-13T02:18Z 27K followers, 2491 engagements

"NAD depletion promotes many age-related diseases Aging is a common reason for declining NAD levels but it's not the root cause Here's a thread on the things that deplete your NAD pool PMID: 33609766"
X Link @siimland 2025-10-13T02:18Z 27K followers, 48.5K engagements

"Supporting pathways X & X is relatively easy - tryptophan and nicotinic acid are abundant in the average person's diet But these pathways don't matter as much as the salvage pathway Why Because the vast majority of your daily NAD is produced by the salvage pathway"
X Link @siimland 2025-10-07T14:33Z 27K followers, 2130 engagements

"If you want to learn everything about boron and all the other essential minerals then check out my book with @drjamesdinic called The Mineral Fix Thanks"
X Link @siimland 2025-10-16T16:42Z 27K followers, 1137 engagements

"The third biggest consumer is SARM1 SARM1 is a protein that promotes axonal degeneration through NAD depletion (PMID: 28334607; PMID: 25908823) Axonal degeneration is an early hallmark of many neurological diseases"
X Link @siimland 2025-10-13T02:18Z 27K followers, 1799 engagements

"PARP1 still has a vital role in longevity by protecting against DNA damage Thus the best approach might be to just try to minimize unnecessary DNA damage to avoid NAD depletion"
X Link @siimland 2025-10-13T02:18Z 27K followers, 1846 engagements

"Heart disease is the #1 cause of death in the world. However death rates from it have dropped 4-5x since the 50s. This is mostly thanks to less smoking better screening and medical prevention. On social media you might get the impression that disease rates are just going up But the truth is that many of the diseases including the #1 cause of death are becoming less deadly"
X Link @siimland 2025-10-15T18:14Z 27K followers, 13.1K engagements

"Whenever you're sleep deprived or feel that you didn't get enough sleep take a larger dose of creatine In this 2011 study on athletes taking XXX mg/kg of creatine after sleeping 3-5 hours reversed the negative decline in skill performance It had equal effects to X mg/kg of caffeine Study: PMID: 21324203 I replicated another study taking XX grams of creatine per day for a week:"
X Link @siimland 2025-10-10T09:26Z 27K followers, 12.4K engagements

"The second biggest consumer of NAD is PARP1 which gets activated during DNA damage to promote DNA repair With age you see an increase in DNA damage PMID: 33512317 PMID: 28336669"
X Link @siimland 2025-10-13T02:18Z 27K followers, 1999 engagements

"Thus the cornerstone to making NAD on autopilot via the salvage pathway is circadian rhythm alignment The top other ways to increase NAD naturally via recycling NAD are: - exercise - calorie restriction - dietary phytonutrients But circadian alignment is key"
X Link @siimland 2025-10-07T14:33Z 27K followers, 1842 engagements

"Real ones know this👇 Daily X% improvement and a healthy lifestyle may seem insignificant in the short term but the effects compound exponentially over time Years of consistent training sleep nutrition and mental health habits will transform you in ways a few good weeks never could And the same goes the other way bad habits compound too in a negative direction over time"
X Link @siimland 2025-10-06T15:14Z 27K followers, 6379 engagements

"Anthocyanins such as luteolinidin and cyanidin-3-O-glucoside inhibit CD38 as well (PMID: 28108596) You get anthocyanins from blue purple and red vegetables and fruits/berries"
X Link @siimland 2025-10-13T02:18Z 27K followers, 2193 engagements

"So you take magnesium glycine and melatonin before bed Yes Siim. And then check your phone in bed for an hour Yes. And wonder why you cant sleep Yes Siim. Must be the wrong form of magnesium"
X Link @siimland 2025-10-12T13:21Z 27K followers, 7072 engagements

"Lastly sirtuins are major consumers of NAD and they require NAD to conduct their processes such as: - DNA repair - cell senescence - metabolic processes - genome stability - mitochondrial function And much more PMID: 28721271 PMID: 27552971"
X Link @siimland 2025-10-13T02:18Z 27K followers, 1550 engagements

"CD38 is the main consumer of NAD and the primary reason NAD declines with age CD38 is a glycoprotein that rises during inflammation CD38 levels increase 2-3-fold during aging which is paralleled by a decrease in NAD PMID: 27304511"
X Link @siimland 2025-10-13T02:18Z 27K followers, 2819 engagements

"Glycine is a multi-system powerhouse: - Lowers inflammation - Lowers blood sugar - Improves sleep - Reduces daytime sleepiness - Eases psychiatric symptoms - Lowers blood pressure - Improves body composition - Supports collagen synthesis and skin - Improves endothelial function Based on a 2024 review of XX human studies Why I megadose glycine for longevity: Graph: PMID: 37851316"
X Link @siimland 2025-10-08T13:03Z 27K followers, 34.3K engagements

"However boosting NMN levels doesnt trigger axonal degeneration itself but actually protects against it after injury (PMID: 30257945) The NAD system has self-inhibitory mechanisms to suppress SARM1 but this gets derailed under pathological conditions (PMID: 33053563)"
X Link @siimland 2025-10-13T02:18Z 27K followers, 1557 engagements

"Disrupting circadian rhythms suppresses the NAD+ dependent SIRT1 gene which then lowers the availability of NAD+ Circadian rhythms of NAD+ are driven by the circadian clock called CLOCK:BMAL1 which regulates the circadian expression of NAMPT PMID: 18662547"
X Link @siimland 2025-10-07T14:33Z 27K followers, 1815 engagements

"The salvage pathway has a bottleneck called NAMPT NAMPT is the rate-limiting enzyme in the NAD salvage pathway meaning it controls how much NAD gets recycled PMID: 17268245"
X Link @siimland 2025-10-07T14:33Z 27K followers, 2121 engagements

"Fit individuals have been seen to experience faster DNA repair after exercise than untrained individuals (PMID: 31248182) However trained individuals maintain higher levels of PARP1 after exercise and they have higher NAD levels (PMID: 37118369)"
X Link @siimland 2025-10-13T02:18Z 27K followers, 1813 engagements

"Polyphenols like those in olive oil and grape seed extract have been shown to reduce LPS and endotoxemia (PMID: 24874372; DOI:10.1016/j.jff.2016.08.011) Flavonoids such as apigenin and quercetin are natural CD38 inhibitors that increase NAD levels (PMID: 23172919)"
X Link @siimland 2025-10-13T02:18Z 27K followers, 2368 engagements

"SARM1 gets activated by a high NMN/NAD ratio (PMID: 33657413) Loss of the enzyme that converts NMN into NAD - NMNAT2 turns on SARM1 triggering axonal degeneration NMNAT2 is essential for healthy axons and it gets rapidly degraded after axonal injury (PMID: 20126265)"
X Link @siimland 2025-10-13T02:18Z 27K followers, 1676 engagements

"NAD is considered a longevity molecule It decreases with age and low levels of NAD accelerate the hallmarks of aging But most people go about raising NAD levels the wrong way Here's a thread about how to maximize your natural NAD production and minimize its loss"
X Link @siimland 2025-10-07T14:33Z 27K followers, 37.4K engagements

"There's a lot more that goes into NAD and its age-related decline You can't avoid it all especially with age that's characterized by increased inflammation and DNA damage But you can reduce the unnecessary loss of NAD"
X Link @siimland 2025-10-13T02:18Z 27K followers, 2599 engagements

"Physical injury inflammation metabolic disorders chronic disease drugs and toxins can inhibit NMNAT2 leading to SARM1 activation (PMID: 35198877) NMN levels also rise after axonal injury (PMID: 25323584)"
X Link @siimland 2025-10-13T02:18Z 27K followers, 1630 engagements

"Lipopolysaccharides (LPS) also known as endotoxin and inflammatory cytokines increase CD38 levels (PMID: 23184288; PMID: 14563702) Aging is characterized by an increase in LPS and inflammation - 'inflammaging' (PMID: 24846769; PMID: 26772806; PMID: 27825999)"
X Link @siimland 2025-10-13T02:18Z 27K followers, 2461 engagements

"Nicotinamide inhibits PARP1 and it also raises NAD levels through the salvage pathway Flavonoids such as quercetin have PARP inhibitory effects as well PMID: 32903806 PMID: 29023372"
X Link @siimland 2025-10-13T02:18Z 27K followers, 1953 engagements