@drjohnm Avatar @drjohnm John Mandrola, MD

John Mandrola, MD posts on X about this is, more than, events, health the most. They currently have [------] followers and [---] posts still getting attention that total [------] engagements in the last [--] hours.

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Social Influence

Social category influence finance 4% travel destinations 3.2% countries 3.2% celebrities 1.6% technology brands 0.8% social networks 0.8% currencies 0.8% stocks 0.8%

Social topic influence this is 2.4%, more than 2.4%, events 2.4%, health 1.6%, we are 1.6%, yaxis #7, the most 1.6%, john #993, copenhagen 1.6%, weight loss 1.6%

Top accounts mentioned or mentioned by @cardiobrief @vprasadmdmph @ejsmd @sensiblemed @venkmurthy @djc795 @charlesornstein @ethanjweiss @sripalbangalore @martymakary @doctorwes @at_truthmatters @usfda @pash22 @kaulcsmc @adamcifu @vkoganpolisci @brsreality @applehelix @medical_nemesis

Top assets mentioned Grin (GRIN) Sanofi (SNY) Novartis AG (NVS) Validity (VAL)

Top Social Posts

Top posts by engagements in the last [--] hours

"Well. This was a flub. I never knew RALES did this though it does not look like the truncation did anything to accentuate the effect size. (ARR death 11%) Even a better example: Generic 4$ per month spironolactone in HFrEF is so good it does not require a doctored graph. https://t.co/E0kE08QdtU Even a better example: Generic 4$ per month spironolactone in HFrEF is so good it does not require a doctored graph. https://t.co/E0kE08QdtU"
X Link 2026-02-15T13:16Z 69.4K followers, 22.6K engagements

"With all due respect this is not my idea of improving critical appraisal 👇🏻 Our latest video in our partnership with @DGlaucomflecken summarizes the POTCAST trial which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free: https://t.co/YzehkItnbS Our latest video in our partnership with @DGlaucomflecken summarizes the POTCAST trial which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular"
X Link 2026-02-04T02:30Z 69.3K followers, 48.8K engagements

"Brilliant in every way. My favorite line: I keep returning to the diagnostic value of time. When the terrain is uncertain and the meaning unclear the best thing to do may be to sit still. Do nothing FTW- @Sensible__Med gets a citation For @tabletmag I wrote about mammograms the epistemic ruins of public health and the implications of unplugging from the consensus-making machine. https://t.co/aKPnvcfrFn For @tabletmag I wrote about mammograms the epistemic ruins of public health and the implications of unplugging from the consensus-making machine. https://t.co/aKPnvcfrFn"
X Link 2026-02-05T21:33Z 69.3K followers, 11.5K engagements

"Before there was an Internet the Internet could not have been imagined. I think we are at such a point with LLM and AI. It took me nearly a decade to scratch the surface of critical appraisal. But I bet similar things could be learned in weeks with an LLM and a motivated person Education will be changed forever Marc Andreessen: There are two ways to think about education. One is at the national level how do you educate all kids But the real question is N = 1: what do you do for one individual kid And for centuries the answer has been obvious. If your goal is to maximize a single"
X Link 2026-02-06T01:45Z 69.3K followers, 12K engagements

"Good thread. Example of why this site is worthwhile. Im torn about this drug class. Honestly I am. Is there a free lunch Sicilians dont seem to need GLP1s GLP-1s are impressively effective but they are not miracle drugs or a standalone intervention that can be adequately delivered a la carte outside primary care. Like much else in medicine their population health benefits will depend on GLP-1s are impressively effective but they are not miracle drugs or a standalone intervention that can be adequately delivered a la carte outside primary care. Like much else in medicine their population"
X Link 2026-02-10T02:02Z 69.3K followers, 17.3K engagements

"Dear @US_FDA @MartyMakary I propose a simple solution to the recent controversy regarding the mRNA vaccine story Let @VPrasadMDMPH do a press conference where he explains his reasoning It would not only help FDA but it would educate the public about proper trials/regulation"
X Link 2026-02-13T12:23Z 69.4K followers, 12.2K engagements

"That slide is even worse than the NEJM KM curves with the truncated y-axis graph inserted on the proper graph. Now show me the curves without massively truncating the y-axis Thank goodness Vinay is at FDA Here the Moderna flu data the FDA refused to review. This is the most important slide from the company's study of its experimental flu vaccine-- exactly the data FDA said it wouldn't even review. And below is a thread of relevant slides from that presentation and links to https://t.co/m70hxSLzDx Here the Moderna flu data the FDA refused to review. This is the most important slide from the"
X Link 2026-02-13T22:54Z 69.4K followers, 152.5K engagements

"RT @venkmurthy: Bingo. This could be akin to stenting vulnerable plaque to "reduce" need for downstream stenting while having no impact on"
X Link 2026-02-14T19:34Z 69.4K followers, [--] engagements

"No one Ive known has been a stronger advocate for the medical profession. Wes. You can rest now. Im proud to call you a friend and colleague. Needless to say I am crushed by this. For years I naively thought we had a chance to end MOC through the courts. 👇 https://t.co/3ZbI8xd046 Needless to say I am crushed by this. For years I naively thought we had a chance to end MOC through the courts. 👇 https://t.co/3ZbI8xd046"
X Link 2026-02-16T02:07Z 69.4K followers, 18K engagements

"RT @pash22: @drjohnm @VPrasadMDMPH and the Battle Over @US_FDA Standards: Why Raising the Evidence Bar Isn't Anti-Science"
X Link 2026-02-16T16:14Z 69.4K followers, [--] engagements

"RT @EJSMD: Cheers to #medtwitter pioneer @doctorwes who's done far more than he'll admit to advocate for working doctors. - First to blog"
X Link 2026-02-16T19:33Z 69.4K followers, [--] engagements

"It shocks me that people think billion-dollar companies should be allowed to clear a lower bar of regulatory approval. It's a head shaker. Another exhibit. A new heart failure drug finerenone was allowed to be tested against placebo instead of spironolactone. This is an egregious regulatory failure. Trust me: you want @VPrasadMDMPH on that wall. Lest you will have pricey less than ideal Rx. It's a malignant condition. https://twitter.com/i/web/status/2021774082031649105 https://twitter.com/i/web/status/2021774082031649105"
X Link 2026-02-12T02:31Z 69.4K followers, 16.2K engagements

"True question: why was this a non-inferiority trial Among patients with diabetes and multivessel coronary artery disease ticagrelor was not noninferior to prasugrel for reducing death myocardial infarction stroke or major bleeding at [--] year after percutaneous coronary intervention. https://t.co/jeC06KXCte https://t.co/k3UhAcjmIP Among patients with diabetes and multivessel coronary artery disease ticagrelor was not noninferior to prasugrel for reducing death myocardial infarction stroke or major bleeding at [--] year after percutaneous coronary intervention. https://t.co/jeC06KXCte"
X Link 2026-02-13T01:22Z 69.4K followers, 28.1K engagements

"All this And its per protocol not intention-to-treat I agree with @drjohnm the compressed y-axis inflates the perception of RRR and disguises the small ARR of 1%. Straight out of How to Lie with Statistics. NEJM solves this by using full y-axis to 100% and then showing the magnified curves as an inset. This should be https://t.co/oZ36TrsbzV I agree with @drjohnm the compressed y-axis inflates the perception of RRR and disguises the small ARR of 1%. Straight out of How to Lie with Statistics. NEJM solves this by using full y-axis to 100% and then showing the magnified curves as an inset. This"
X Link 2026-02-14T19:25Z 69.4K followers, 12.2K engagements

"I did not think it would be necessary to make the JAMA coffee paper a study-of-the-week but the media reaction was shocking. On @Sensible__Med Here you go cc @AlexBerenson https://www.sensible-med.com/p/coffee-is-great-but-it-does-not-prevent https://www.sensible-med.com/p/coffee-is-great-but-it-does-not-prevent"
X Link 2026-02-16T13:33Z 69.4K followers, 10.1K engagements

"RT @anish_koka: Prasad's point that he's been making for more than a decade is that FDA approval has been gamed in a variety of ways one o"
X Link 2026-02-16T16:14Z 69.4K followers, [--] engagements

"Seems important 👇🏻 [--] yrs after surgery or #TAVR with CoreValve/Evolut low-risk AS pts showed no difference in all-cause mortality or disabling #stroke in the Evolut Low-Risk trial. However reinterventions were higher after TAVR largely driven by increased AR. https://t.co/bekmaogS1O #JACC https://t.co/5COiLCcQUK [--] yrs after surgery or #TAVR with CoreValve/Evolut low-risk AS pts showed no difference in all-cause mortality or disabling #stroke in the Evolut Low-Risk trial. However reinterventions were higher after TAVR largely driven by increased AR. https://t.co/bekmaogS1O #JACC"
X Link 2026-02-16T22:37Z 69.4K followers, [----] engagements

"I see widespread criticism of @VPrasadMDMPH and FDA decision to not review Moderna vaccine Why has no one on this website considered the potential upside of requiring industry to fund and conduct more rigorous trials Would this not improve trust in vaccines If we are to have an FDA (I get the libertarian case against) should regulation not be rigorous See this thread from @kaulcsmc on dubious FDA device approvals Exhibit B: one of the top HF drugs passed muster in only one trial that had serious limitations. That's a regulatory failure IMO because we aren't sure that generic replacements"
X Link 2026-02-11T12:44Z 69.4K followers, 24.8K engagements

"You all should go out to dinner w VP. No more than one glass of wine. Talk. Listen. Hed teach you a lot about the tricks of critical appraisal Spoke to @l_e_whyte about FDA today. Prasads decisions in the rare disease space call into question whether the commissioner is committed to rare disease or just saying what the community wants to hearhttps://t.co/ta1VRb9gLf Spoke to @l_e_whyte about FDA today. Prasads decisions in the rare disease space call into question whether the commissioner is committed to rare disease or just saying what the community wants to hearhttps://t.co/ta1VRb9gLf"
X Link 2026-02-12T04:05Z 69.4K followers, 19.7K engagements

"Well David heres the (ITT) KM from the Jupiter trial of rosuvastatin. And at least its a MACE endpoint not some nebulous ILI. @venkmurthy @drjohnm Venkatesh-you may be right about th ad hominem attack but objectively its absurd for Mandrola to critique there only be a 1% ARR reduction when the control rate is 2.5% -its cynical and intellectually dishonest attack @venkmurthy @drjohnm Venkatesh-you may be right about th ad hominem attack but objectively its absurd for Mandrola to critique there only be a 1% ARR reduction when the control rate is 2.5% -its cynical and intellectually dishonest"
X Link 2026-02-15T01:34Z 69.4K followers, 20.9K engagements

"Even a better example: Generic 4$ per month spironolactone in HFrEF is so good it does not require a doctored graph. @drjohnm I agree rosuvastatin is a good drug but here the baseline rate in control is 2.5% so mathematically ARR would max out at 2.5%. However very few therapies in medicine have been [--] or [--] or 100% effective even against placebo let alone active control like here-1/2 @drjohnm I agree rosuvastatin is a good drug but here the baseline rate in control is 2.5% so mathematically ARR would max out at 2.5%. However very few therapies in medicine have been [--] or [--] or 100%"
X Link 2026-02-15T02:23Z 69.4K followers, 194.5K engagements

"Happy to amplify the Mayo program with Dr Ackerman. One of the most helpful and generous genetic arrhythmia experts in the US. I call him the John Roberts of genetic arrhythmias It was such a treat to have your family as my first patient of my February [----] rotation here @MayoClinic in #Jacksonville #Florida. I love it down here and your daughters smile & hug reminded me quickly why I love what I do so very much. #HappyValentinesDay to all my families. It was such a treat to have your family as my first patient of my February [----] rotation here @MayoClinic in #Jacksonville #Florida. I love it"
X Link 2026-02-15T02:45Z 69.4K followers, [----] engagements

"@AlexBerenson Alex. Im a huge fan of your work but these are awful studies. Fatally confounded and implausible. I explain on the last topic on TWIC. https://podcasts.apple.com/us/podcast/this-week-in-cardiology/id991125169i=1000749650313 https://podcasts.apple.com/us/podcast/this-week-in-cardiology/id991125169i=1000749650313"
X Link 2026-02-16T00:31Z 69.4K followers, 20.5K engagements

"RT @LocasaleLab: Taking a graph out of context to imply deception isnt accountability. Its performative gotcha journalism. This is the l"
X Link 2026-02-16T02:34Z 69.4K followers, [--] engagements

"Theres a nearly 3% higher rate of death and disabling stroke in the TAVI arm. I get the p value but my brain has trouble thinking no difference JACC just published 6yr outcomes from the Evolut Low Risk Trial w/additional 7yr follow-up. [--] endpoint (death or disabling stroke): no difference through [--] years. Imp finding: A divergence in reintervention appears beyond year five. @JACCJournals https://t.co/OE0g4ar29f JACC just published 6yr outcomes from the Evolut Low Risk Trial w/additional 7yr follow-up. [--] endpoint (death or disabling stroke): no difference through [--] years. Imp finding: A"
X Link 2026-02-16T23:08Z 69.4K followers, 18.8K engagements

"As promised here is a slew of content .re the PLATO trial of ticagrelor vs clopidogrel in patients with ACS This all occurred in [----] early in my critical appraisal learning. Revisiting PLATO controversy is super important--both clinically and epistemologically"
X Link 2024-12-23T12:53Z 67.2K followers, 13.2K engagements

"This is why B+ students make the best bedside clinicians (IMHO) 👇🏻 I'm not up on the H-1B debate. However I will say this: though I don't entirely disagree with what is said below this is not at all a zero-sum game. There is an indispensable risk-taking outsized personality motorcycle-jumping daredevil cocky confident American attitude I'm not up on the H-1B debate. However I will say this: though I don't entirely disagree with what is said below this is not at all a zero-sum game. There is an indispensable risk-taking outsized personality motorcycle-jumping daredevil cocky confident"
X Link 2024-12-28T23:47Z 67.2K followers, 14.6K engagements

"Good news: Professor Jha's paper and Post made the Study-of-the-Week column on @Sensible__Med There were many lessons to learn from that "useful data" that "saved American lives" There seems to be a debate on Twitter about the value of high skilled immigration in the US So here's a bit of data in case that's useful If you're hospitalized and your physician graduated from a foreign medical school You are LESS likely to die than if your physician There seems to be a debate on Twitter about the value of high skilled immigration in the US So here's a bit of data in case that's useful If you're"
X Link 2024-12-30T12:26Z 67.2K followers, 68.5K engagements

"Good luck and Wes thank you for your work toward saving our profession Saying a prayer that justice prevails for US physicians harmed by the ABMS Maintenance of Certification (MOC) monopoly. Oral arguments in Lazarou v ABPN (24-1994) are set for 09:30 CST tomorrow at the US Court of Appeals for the 7th Circuit [---] S. Dearborn Street Chicago IL. Saying a prayer that justice prevails for US physicians harmed by the ABMS Maintenance of Certification (MOC) monopoly. Oral arguments in Lazarou v ABPN (24-1994) are set for 09:30 CST tomorrow at the US Court of Appeals for the 7th Circuit [---] S."
X Link 2025-01-14T11:52Z 67.3K followers, [----] engagements

"Best Tweet of the month 👇🏻 Try not putting your patient on it and see the reaction of your attending (from a medical and medicolegal perspective) When we move from EBM to CYAM (cover your a** medicine) this is what we end up doing Defensive medicine + strict litigation + resource rich country = bad combo Try not putting your patient on it and see the reaction of your attending (from a medical and medicolegal perspective) When we move from EBM to CYAM (cover your a** medicine) this is what we end up doing Defensive medicine + strict litigation + resource rich country = bad combo"
X Link 2025-01-16T12:28Z 67.3K followers, [----] engagements

"When to stop antiplatelet therapy when patients have AF and take oral anticoagulation is a tough question New meta-analysis of [--] RCTs suggest OAC alone is enough. That's not what happens in my zip code. We may need to change. Link in next post"
X Link 2025-01-18T12:18Z 67.2K followers, 29.2K engagements

"Thanks to the fellows for the invite. Its an extra-big honor to be invited by young people. Tour de force lecture of AFib from @drjohnm at @umichCVC Cardiology Grand Rounds for the Fellows Visiting Professorship Love his Voltaire approach https://t.co/v0mwToweKw Tour de force lecture of AFib from @drjohnm at @umichCVC Cardiology Grand Rounds for the Fellows Visiting Professorship Love his Voltaire approach https://t.co/v0mwToweKw"
X Link 2025-01-23T18:57Z 67.2K followers, [----] engagements

"What a massive opportunity for ecological or quasi-experimental studies. Reviewing evidence every week I suspect fewer studies might not harm the medical scientific enterprise. Cc @elonmusk NIH just made a drastic change to indirect cost rates reducing the rate to 15% a significant cut from the 60%+ some institutions charge. This will have a devastating effect on the nations medical research infrastructure. @ResearchAmerica @AAMC @YaleMed https://t.co/GQidBBR6C8 NIH just made a drastic change to indirect cost rates reducing the rate to 15% a significant cut from the 60%+ some institutions"
X Link 2025-02-08T01:34Z 67.3K followers, 18.2K engagements

"One of the most important concepts in Medicine is asymmetric risk. Eg: esophageal injury after AF ablation =1/10000. That is low but since its death rate is 90% its a HUGE risk. Its why PFA is replacing thermal ablation in the left atrium even tho PFA efficacy is no better No. A "1% to 2.3% chance" is not an "extremely low possibility". It may be for an individual but not for the collective. Depending on impact if we had significant ones every few million years we would not be there. No. A "1% to 2.3% chance" is not an "extremely low possibility". It may be for an individual but not for the"
X Link 2025-02-08T15:30Z 67.4K followers, 40.3K engagements

"Something to celebrate: a group EP photo without a shiny happy industry rep and their banner Muscular arquitecture of the left atrium the 🔹subepicardial septopulmonary bundle overlaps with the 🔹subendocardial septoatrial bundle . Sharing with an enthusiastic group of young EP. Understanding anatomy is key to advancing the treatment of atrial fibrillation https://t.co/XHcfo8oPYM Muscular arquitecture of the left atrium the 🔹subepicardial septopulmonary bundle overlaps with the 🔹subendocardial septoatrial bundle . Sharing with an enthusiastic group of young EP. Understanding anatomy is key"
X Link 2025-02-19T00:39Z 67.4K followers, 11.9K engagements

"Another thing about zero fluoro ablation is that is industry friendly and higher cost because you have to use an intracardiac echo catheter and 3d mapping. Complications happento EVERY operator but I stand by my contention that flouroless ablation is an unnecessary parlor trick. 1-2 min of X-ray is not a problem. Plus the same operator doing a zero fluoro case often does a CRT device w 45+ min of fluoro. Complications happento EVERY operator but I stand by my contention that flouroless ablation is an unnecessary parlor trick. 1-2 min of X-ray is not a problem. Plus the same operator doing a"
X Link 2025-02-23T19:09Z 67.4K followers, 24.8K engagements

"Highly recommended 👇🏻 I dont think a CAC scan is ever very useful but this well written paper on when NOT to do a scan is quite good b/c I see errors like these every week. If you do CAC when PCE is 20% you fail Medicine [---] Measurement of coronary artery calcium (CAC) score among adults without ASCVD and of intermediate risk as well as borderline risk in certain cases can help refine risk stratification when a clinical decision is uncertain. https://t.co/wwRrJ7gfCL https://t.co/GTL1q3wLJv Measurement of coronary artery calcium (CAC) score among adults without ASCVD and of intermediate risk"
X Link 2025-03-05T18:08Z 67.4K followers, 35.7K engagements

"Look at the y-axis. This may be another trial with statistical significance but not clinical significance. Pts have established disease. And no difference in CVD or major kidney secondary composite. Is it worth the cost I don't think so. #ACC25 Presented at #ACC25: Among participants with type [--] diabetes and cardiovascular disease chronic kidney disease or both oral semaglutide (14 mg) was associated with a lower risk of cardiovascular events than placebo after [--] years of follow-up. Full SOUL phase 3b trial https://t.co/nEvdGumry9 Presented at #ACC25: Among participants with type [--] diabetes"
X Link 2025-03-30T08:58Z 67.7K followers, 22.2K engagements

"Many choices for trials to highlight the past week but I love this one. Again from (where else) Copenhagen If I had a dollar for every time a sent a pt with heart failure for thoracentesis for pleural effusion Boom. No benefit in an RCT"
X Link 2025-04-05T13:25Z 67.6K followers, 54.7K engagements

"@DavidDobiesMD Link in replies b/c links get down graded on the new @x"
X Link 2025-04-05T13:31Z 67.7K followers, [----] engagements

"Society will burn $$ trying to incrementally prevent coronary death No imaging test or AI will improve outcomes over and above eating well exercising and not smoking ( statin) Coronary events are stochastic. Live like Sicilians and don't waste $ or time micromanaging Per Cleerly health the company used to define NCPV (non calcified plaque volume) : Increasing non-calcified plaque and low-density non-calcified plaque is prognostic for future major adverse cardiac events Graph depicts LDL average of [---] probably due to diet. Would be https://t.co/PYqefGRMoo Per Cleerly health the company used"
X Link 2025-04-12T20:41Z 67.6K followers, 33.3K engagements

"Every minute you are in a scanner or getting blood drawn or searching the Internet for information on coronary disease CAC or plaque volume you could be on a bike"
X Link 2025-04-12T21:12Z 67.6K followers, 14.6K engagements

"@BrentAWilliams2 When I walk the halls of the hospital I wonder how many of the people I see (with badges) participate in helping sick people get well"
X Link 2025-04-18T01:03Z 67.7K followers, [----] engagements

"Good question and interesting paper. 👇🏻 My [--] cents Lp (a) is a marker more than a causal agent. I predict w low levels of conviction that Lp (a) lowering trials will be meh Lp(a) levels not associated with cardiovascular or all cause death when LDL and CRP adjusted for. Is Lp(a) just a marker of risk or is it causal https://t.co/77kRFHZNiF https://t.co/sd6FQ6MgIh Lp(a) levels not associated with cardiovascular or all cause death when LDL and CRP adjusted for. Is Lp(a) just a marker of risk or is it causal https://t.co/77kRFHZNiF https://t.co/sd6FQ6MgIh"
X Link 2025-04-19T09:35Z 67.7K followers, 34.4K engagements

"This is an important document. MRI access for pts w cardiac devices can be severely limited in some geographies. The problem is blatant disregard of evidence. Its a good role for our professional societies. Time for sticks b/c carrots have failed. HRS Call to Action: Improved MRI Access for Patients with Cardiovascular Implantable Electronic Devices https://t.co/8hCZpRFthY HRS Call to Action: Improved MRI Access for Patients with Cardiovascular Implantable Electronic Devices https://t.co/8hCZpRFthY"
X Link 2025-05-05T16:49Z 67.7K followers, [----] engagements

"Even if the drug did cause loss of muscle mass if you are treating serious obesity-related disease (heart kidney liver etc) the net benefit would be positive A drug has the same biology; the docs job is to select pts most likely to incur a "net benefit" https://www.sensible-med.com/p/two-important-concepts-in-medical The biggest controversy surrounding GLP-1 drugs is whether they cause excess muscle loss🧵 We now have an answer: "No." Compared to weight loss by diet or surgery GLP-1RA-induced weight loss is comparable in its effects on lean body mass. https://t.co/zBF4a8ORNL"
X Link 2025-05-10T20:27Z 67.7K followers, 39.9K engagements

"Impressive is the current administrations choice of @DrJBhattacharya @MartyMakary and @VPrasadMDMPH to be in key healthcare leadership roles. US health especially non-communicable disease is in need of sweeping change. https://www.thefp.com/p/ahead-of-the-curveutm_campaign=posts-open-in-app&r=1mem2 https://www.thefp.com/p/ahead-of-the-curveutm_campaign=posts-open-in-app&r=1mem2"
X Link 2025-05-13T23:35Z 67.7K followers, 11K engagements

"@mdonnino My secret weapon"
X Link 2025-05-20T18:54Z 68.1K followers, [---] engagements

"Good morning all. After yesterday's excitement about the CHALLENGE exercise trial here is my critical appraisal on @Sensible__Med #ASCO25"
X Link 2025-06-02T11:54Z 68K followers, 120K engagements

"@DrSiyabMD Not at all. @VPrasadMDMPH has always said a) more things than we think can be studied in an RCT b) there is a clear role for observational studies eg vaccine safety"
X Link 2025-06-07T22:42Z 67.9K followers, [---] engagements

"Based on Stage [--] its going to be a great summer of bike racing. That was some racing today. @drjohnm The organizers are surely satisfied with how stage [--] played out @drjohnm The organizers are surely satisfied with how stage [--] played out"
X Link 2025-06-09T00:56Z 68K followers, [----] engagements

"Sometimes. to fix really tough problems you have to start over completely"
X Link 2025-06-09T21:31Z 68K followers, [----] engagements

"If you don't find these public conversations impressive and optimistic you are biased. If public health is anything like the clinic there is nothing more vital than listening and clear humble communication. Good on @MartyMakary @VPrasadMDMPH In a new FDA Direct conversation @DrMakaryFDA outlines his priorities for a new FDA one that cuts unnecessary delays and puts patients first. https://t.co/mBMkEGhGUw In a new FDA Direct conversation @DrMakaryFDA outlines his priorities for a new FDA one that cuts unnecessary delays and puts patients first. https://t.co/mBMkEGhGUw"
X Link 2025-06-10T19:47Z 68K followers, 22.4K engagements

"Im super optimistic about @VPrasadMDMPH having important roles in regulatory decisions A) Hes literally the smartest MD Ive met B) Hes been a clinician C) He has common sense (a Hoosier once) D) Isnt optimism better than pessimism FDA Commish Marty Makary handing out job titles to Vinay Prasad like an Oprah holiday show. Prasad is now CMO and CSO of the FDA adding to his CBER chief responsibilities. Remember when CDER was sorta important at the FDA https://t.co/BAwSubpaF2 via @LizzyLaw_ FDA Commish Marty Makary handing out job titles to Vinay Prasad like an Oprah holiday show. Prasad is now"
X Link 2025-06-18T21:55Z 68K followers, 35.4K engagements

"Well well @RFRedberg it took a bit but your former journal has fallen. What a conflicted utter mess. Embarrassing. Hospitalized patients of physicians with higher preliminary Longitudinal Knowledge Assessment scores experienced lower 7-day mortality and readmission rates. https://t.co/ULou2QtU1b https://t.co/nXV6iXRrqB Hospitalized patients of physicians with higher preliminary Longitudinal Knowledge Assessment scores experienced lower 7-day mortality and readmission rates. https://t.co/ULou2QtU1b https://t.co/nXV6iXRrqB"
X Link 2025-06-20T23:33Z 68K followers, 24.6K engagements

"Here is Claude's opinion on COI @JAMAInternalMed @WillyRontgen @JAMAInternalMed @AaronGoodman33 @VPrasadMDMPH @doctorwes @kardiologykazi No COIs from the ABIM employees. I guess that must mean they work as volunteers ()/. @drjohnm @AaronGoodman33 https://t.co/El0AGrzvAK @WillyRontgen @JAMAInternalMed @AaronGoodman33 @VPrasadMDMPH @doctorwes @kardiologykazi No COIs from the ABIM employees. I guess that must mean they work as volunteers ()/. @drjohnm @AaronGoodman33 https://t.co/El0AGrzvAK"
X Link 2025-06-22T18:35Z 68K followers, 23.2K engagements

"This is very sad. I thoroughly enjoyed my two visits w Dr Flapan in Edinburgh. You could easily tell he was a doctors doctor. An honor to contribute to his meeting at @RCPEdin Very sad to hear of the sudden death of Dr Andrew Flapan Consultant Cardiologist in Edinburgh. As a young doctor he was a major inspiration to me. Later I had a great dinner with him at @RCPEdin the night before I gave a lecture. A great loss 😢 https://t.co/BmxEevGglR Very sad to hear of the sudden death of Dr Andrew Flapan Consultant Cardiologist in Edinburgh. As a young doctor he was a major inspiration to me. Later"
X Link 2025-06-25T19:18Z 68K followers, [----] engagements

"This is such an important observation. On many levels. I will discuss on This Week in Cardiology. Teaser thoughts: A) Recall that as treatment of a problem gets better screening becomes less important. B) All humans die; so if they don't die of cancer and AMI that leaves HF. C) What are the roles of higher rates of statin use Thanks for sharing ET Heart disease is still the #1 killer in the United States but it's no longer from heart attacks.instead it's from heart failure and arrhythmias https://t.co/DJ92PYjwIq https://t.co/RkFGtSYDIk Heart disease is still the #1 killer in the United States"
X Link 2025-06-25T20:52Z 68K followers, 20.1K engagements

"@BrentAWilliams2 Good point. Docs would be wise to recognize that and pick fields less likely to be disrupted. Though still getting the right diagnosis is a hugely history-driven effort and I have trouble imagining LLM doing histories"
X Link 2025-06-30T21:06Z 68K followers, [---] engagements

"While we were busy celebrating America's birthday PRAGUE [--] was published AF ablation vs weight loss. You might think it is a win for ablation. I don't. My take @Sensible__Med is in the next link. Results support a medically conservative approach to patients with obesity and AF"
X Link 2025-07-07T11:25Z 68.1K followers, [----] engagements

"https://www.sensible-med.com/p/prague-25-a-negative-trial-for-weight https://www.sensible-med.com/p/prague-25-a-negative-trial-for-weight"
X Link 2025-07-07T11:25Z 68K followers, [----] engagements

"Thank goodness calmer heads (the payers) are prevailing. Its sad for the profession that we are not the gate keepers of high value care. Renal denervation for HTN was approved the FDA over [--] months ago. But very few cases performed in the US despite a theoretical eligible population 100M patients for this therapy. We cover the elephant in the room: reimbursement in @cardiacinterv. https://t.co/5OdKP7YEe6 Renal denervation for HTN was approved the FDA over [--] months ago. But very few cases performed in the US despite a theoretical eligible population 100M patients for this therapy. We cover"
X Link 2025-07-10T00:44Z 68.1K followers, [----] engagements

"Ive been studying medical studies for more than a decade and @VPrasadMDMPH is one of the best at judging evidence I have seen. Hes a huge asset for proper regulation. Highest confidence 👇🏻 FDA rejecting $CAPR deramiocel follows STAT reporting last month. The ouster of the FDAs chief regulator of cell and gene therapies earlier this week came immediately after a disagreement with her boss over the review of a cell therapy for Duchenne muscular dystrophy STAT FDA rejecting $CAPR deramiocel follows STAT reporting last month. The ouster of the FDAs chief regulator of cell and gene therapies"
X Link 2025-07-11T22:39Z 68.1K followers, 19.3K engagements

"👇🏻👇🏻Note to young docs: if you arent doing something that a NP w/AI cant do you are in big trouble (Tune in this week to @Sensible__Med we have a scary post coming) The latest sign that primary care by doctors is over in our nation. I have an appointment next week with the Dr I love. Outstanding doctor. When I went to reschedule the next available appointment is in April [----]. It's all ok but it's a very clear sign that we are moving The latest sign that primary care by doctors is over in our nation. I have an appointment next week with the Dr I love. Outstanding doctor. When I went to"
X Link 2025-07-12T21:35Z 68.1K followers, 73.4K engagements

"@AnilMakam I learned the process in Denmark. Always take time in b/w cases"
X Link 2025-07-15T23:20Z 68.1K followers, [---] engagements

"Truly curious question for my prevention colleagues. How much does ApoB modify 10-year risk calculations If it isnt a lot why do we measure it at all"
X Link 2025-07-21T23:37Z 68.2K followers, 19.2K engagements

"This is why plausibility is the most dubious reason to do something in Medicine. Not only did this anti-inflammatory not decrease AF it INCREASED AF. Rule [--] in EBM: beware of doing things only because they make sense. https://www.ahajournals.org/doi/10.1161/CIRCEP.124.013378 https://www.ahajournals.org/doi/10.1161/CIRCEP.124.013378"
X Link 2025-07-26T23:13Z 68.2K followers, 15.6K engagements

"Dr G most of @danielleofri criticisms are about processes or surrogate measures. Why not give the new leadership a chance Theyve had mere months. I propose waiting for outcomes. Its not like health outcomes have been stellar. And surely you dont think previous leadership was apolitical. Medical professionals can no longer fully trust federal health guidance and our patients are the ones who will suffer the most. Excellent read from @danielleofri on the reality for clinicians as NIH CDC FDA recs are put under political controls. https://t.co/V0gSsea8Ov Medical professionals can no longer fully"
X Link 2025-07-29T16:39Z 68.2K followers, [----] engagements

"Imagine a 5-hour training ride and NOT having a cheeseburger fries and a vanilla milk shake after the ride. Pauline Ferrand Prevot: I know that this shape that I have now I will not keep forever. It's just for the Tour de France. It's also my job to be the best as possible. We know this is an endurance sport and to climb you need to have a high watts per kilogram. "I don't want to https://t.co/AZUTTryl4J Pauline Ferrand Prevot: I know that this shape that I have now I will not keep forever. It's just for the Tour de France. It's also my job to be the best as possible. We know this is an"
X Link 2025-08-05T01:28Z 68.5K followers, [----] engagements

"Under appreciated toxicity so often related to dose. See also water and oxygen Weightlifting is "life insurance ". But lifting too much & too often is a death sentence. The poison is in the dose. Weightlifting is "life insurance ". But lifting too much & too often is a death sentence. The poison is in the dose"
X Link 2025-08-11T23:17Z 68.3K followers, [----] engagements

"Grin Finerenone reduced the need for loop diuretic dose intensification and lowered the average loop diuretic dose across all diuretic subgroups in patients with HFmrEF/HFpEF. https://t.co/7ivf3aYVZ7 https://t.co/PpIaI2CU13 Finerenone reduced the need for loop diuretic dose intensification and lowered the average loop diuretic dose across all diuretic subgroups in patients with HFmrEF/HFpEF. https://t.co/7ivf3aYVZ7 https://t.co/PpIaI2CU13"
X Link 2025-08-15T00:53Z 68.3K followers, 13.7K engagements

"This seems kind of important. PFA = cardioselective Is it seen with other brands of PFA Im asking. High Incidence of Phrenic Nerve Injury in Patients Undergoing Pulsed Field Ablation for Atrial Fibrillation #OpenAccess https://t.co/KMAoBdriHl https://t.co/T1tO0axHv2 High Incidence of Phrenic Nerve Injury in Patients Undergoing Pulsed Field Ablation for Atrial Fibrillation #OpenAccess https://t.co/KMAoBdriHl https://t.co/T1tO0axHv2"
X Link 2025-08-16T18:53Z 68.2K followers, 19.4K engagements

"I covered this paper on TWIC podcast. Most relevant observations: [--] in [--] pts w LAAO die with in a year. Thats a lot of people who get no benefit Nearly half pts die at [--] years. Again LAAO is long term therapy. Mortality many fold higher than stroke or bleeding And this was from 6-8 years ago. We are definitely implanting even older pts now. Pt selection for LAAO in the US is terrible. Cc @AndrewFoy82 @MRuzieh Our study showing that rates of stroke after LAAO remain steady over long term 5- year follow-up demonstrating the durable effectiveness of the therapy. Our study showing that rates of"
X Link 2025-08-24T11:31Z 68.5K followers, 28.5K engagements

"@ProfHayward @adamcifu @Wil_Ward_ Exactly as I thought. I would love to see a placebo-controlled trial of restarting SSRI vs placebo in patients who have symptoms after discontinuation"
X Link 2025-08-24T19:47Z 68.3K followers, 16.8K engagements

"No trial better explains the importance of evidence than REVIVED BCIS. It boggles my mind that it was negative @divaka_perera is correct but try telling 99% of American cardiologists We still cath new LV dys pts TO FIND LESIONS TO REVASC despite negative trials #ESC2025 @divaka_perera makes a strong case: routine #PCI should not be performed in asymptomatic pts with LV dysfunction (even with viability). It does NOT improve prognosis Evidence should guide practice: The earth is not flat 🌎 #ESCCongress @escardio @drjohnm https://t.co/OlPWi3WZc9 @divaka_perera makes a strong case: routine #PCI"
X Link 2025-08-29T07:52Z 68.4K followers, 45K engagements

"Cooking w gas today at #esccongress Writing outside akin to riding w a tailwind. Beta blocker thoughts coming any moment. Just sent in my post on the null results of REFINE ICD. Gosh does the primary prevention ICD need a fresh look. Stay tuned"
X Link 2025-08-31T14:31Z 68.4K followers, [----] engagements

"Dear #ESCCongress -- thx for such a great meeting. We all have a lot of work to do digging into all these trials. There are so many. Here are my first three: DIGIT HF REBOOT/BETAMI-DANBLOCK REFINE ICD https://www.medscape.com/viewarticle/time-nix-primary-prevention-icd-2025a1000mz2 https://www.medscape.com/viewarticle/beta-blockers-post-mi-clear-clinical-message-2025a1000mz0 https://www.medscape.com/viewarticle/five-big-messages-digit-hf-trial-2025a1000mwt https://www.medscape.com/viewarticle/time-nix-primary-prevention-icd-2025a1000mz2"
X Link 2025-09-01T11:33Z 68.4K followers, 14.6K engagements

"I am 💯 behind free speech. But pharmaceutical (AND DEVICE) ads are an abomination. I support @MartyMakary @VPrasadMDMPH @US_FDA in their efforts to stop deceptive advertising. Optimism is in short supply these days but new FDA makes me hopeful Endless pharmaceutical ads on TV are distorting the doctor patient-relationship and driving up health care costs for all. Why @US_FDA is now taking bold action: https://t.co/cRaSZD939W Endless pharmaceutical ads on TV are distorting the doctor patient-relationship and driving up health care costs for all. Why @US_FDA is now taking bold action:"
X Link 2025-09-13T00:43Z 68.5K followers, 14.4K engagements

"The problem is you cant read it b/c its behind a paywall. Sad. Stuff like this should be free. Thought provoking piece in BMJ. Should we spend less time on primary prevention to spend more time to treat the sick. Would love to know the thoughts of sensible medicine @adamcifu @drjohnm https://t.co/KN6Dle2SCt Thought provoking piece in BMJ. Should we spend less time on primary prevention to spend more time to treat the sick. Would love to know the thoughts of sensible medicine @adamcifu @drjohnm https://t.co/KN6Dle2SCt"
X Link 2025-09-13T22:16Z 68.4K followers, [----] engagements

"Biggest move today in clinic: Stopping ASA in pts on DOAC AQUATIC = most important trial of the year. https://www.medscape.com/viewarticle/aquatic-finds-clear-harm-aspirin-anticoagulation-combo-2025a1000ntq https://www.medscape.com/viewarticle/aquatic-finds-clear-harm-aspirin-anticoagulation-combo-2025a1000ntq"
X Link 2025-09-19T18:35Z 68.5K followers, 29.6K engagements

"You dont like your trial results. Just add a meta-analysis to the results. My take on @Sensible__Med Cc @kaulcsmc https://www.sensible-med.com/p/rescuing-a-non-significant-trial https://www.sensible-med.com/p/rescuing-a-non-significant-trial"
X Link 2025-09-22T13:02Z 68.4K followers, 15.9K engagements

"I enjoy CAs feed. Solid thinking. I dont travel near as much but when I do the higher societal trust relative to Louisville KY in say Rzeszow Poland or Copenhagen or Lubeck is shocking. Maybe one (potential) solution is that our future leaders travel more. No High Trust is not only a euphemism for low crime. It means self regulating behavior and a level of trust between citizens where the state doesn't always need to get involved to "clamp down on crime" I don't know what Richard is these days but I believe he is a No High Trust is not only a euphemism for low crime. It means self regulating"
X Link 2025-09-24T23:52Z 68.5K followers, [----] engagements

"Gosh darn it @WSJ that bad guy @VPrasadMDMPH is so tough on new drugs that FDA just approved a new cancer drug that had no effect on survival over standard therapy No worries Im sure its not costly and free of adverse effects. U.S. FDA approves Inluriyo (imlunestrant) for adults with ER+ HER2- ESR1-mutated advanced or metastatic breast cancer https://t.co/7CUmWEVAzQ U.S. FDA approves Inluriyo (imlunestrant) for adults with ER+ HER2- ESR1-mutated advanced or metastatic breast cancer https://t.co/7CUmWEVAzQ"
X Link 2025-09-25T23:28Z 68.5K followers, 29.7K engagements

"The main reason to read this paper is as an example of observational study run amok Among [---] pts at a single center With all due respect please resist the urge to do (and publish) such folly. Look at the early curve separation https://www.jacc.org/doi/10.1016/j.jchf.2025.102573 Retrospective analysis of patients with #HFrEF with ICD #GLP1RA use was associated with significant in heart rate & number of nonsustained ventricular events and total shock/antitachycardia pacing therapies @JACCJournals https://t.co/iz94iEF3v5 https://www.jacc.org/doi/10.1016/j.jchf.2025.102573 Retrospective analysis"
X Link 2025-09-30T00:32Z 68.6K followers, 38.8K engagements

"Since Im old enough to have used mexiletine I loved reading these observations. Not sure of clinical utility in the PFA era though. Adding mexiletine to dofetilide reduces QTc prolongation and boosts AF-free time showing safety and efficacy of the combination therapy. #AHAJournals #Epeeps https://t.co/oBoxHgpRJ8 https://t.co/lu0rekFUqe Adding mexiletine to dofetilide reduces QTc prolongation and boosts AF-free time showing safety and efficacy of the combination therapy. #AHAJournals #Epeeps https://t.co/oBoxHgpRJ8 https://t.co/lu0rekFUqe"
X Link 2025-09-30T22:42Z 68.6K followers, 12.3K engagements

"Super interesting 👇🏻 The 12-lead ECG is an amazing medical test. No harm. No pain. And like $25. R-wave amplitude changes in lead aVL predict outcomes in cardiac resynchronization therapy: Exploring the role of papillary muscle dyssynchrony and mitral regurgitation @BPTHOSP @MassGeneralNews #EPeeps https://t.co/vBOVe9t0kj https://t.co/jTHZOF3UVN R-wave amplitude changes in lead aVL predict outcomes in cardiac resynchronization therapy: Exploring the role of papillary muscle dyssynchrony and mitral regurgitation @BPTHOSP @MassGeneralNews #EPeeps https://t.co/vBOVe9t0kj https://t.co/jTHZOF3UVN"
X Link 2025-10-03T00:07Z 68.6K followers, 13.1K engagements

"Again we can debate ideal cholesterol levels but with all due respect this is not a smart take. 👇🏻 You cant assume causal paths from cholesterol to death in that population study This is the chart the medical and drug community doesnt want you to understand. It shows hazard ratios (your risk of death) compared to total cholesterol levels for men and women. 👉 A hazard ratio of [---] = baseline risk. 👉 Above [---] = higher risk. 👉 Below [---] = lower risk. https://t.co/CjZQKC4UZO This is the chart the medical and drug community doesnt want you to understand. It shows hazard ratios (your risk of"
X Link 2025-10-04T19:10Z 68.6K followers, 20.9K engagements

"@BaoGTran Yes true but the vast majority can be controlled on lisinopril HCTZ and amlodipine"
X Link 2025-10-04T19:52Z 68.6K followers, [---] engagements

"@djc795 @DrOzanDemir @ColletCarlos @OPCILive @CircIntv @SVRaoMD @wfearonmd @mmamas1973 @GreggWStone @JEscaned @divaka_perera @DrHaseebRahman1 @AishSinha1 @K_DeSilva @achir76 @sven_plein @mattlkw @DrMattRyan @drkogallagher Curious how often are physiologic tests done for LMCA"
X Link 2025-10-05T00:54Z 68.6K followers, [---] engagements

"JSP raises a good point. Medical tests like medications should not be considered bad or good. Rather its the USE of these interventions. The problem w CAC is much more its unwise usage. If all clinicians were like JSP we wouldnt have problems of overuse of downstream testing. But even without misuse I would also hold that heart disease would hardly be affected. Its why you would need an RCT of a million people to have the power to show CAC benefit over a simple risk equation. OK. but in [--] years [--] [--] [--] [--] years In hands of a conservative cardiologist who educates patient and avoids"
X Link 2025-10-06T18:30Z 68.6K followers, 10.8K engagements

"I could not disagree w this more. Low dose or not it defies common sense to use radiation to persuade a pt. A) Heart disease is not anatomical. Its systemic and responds to systemic Rx B) No empirical evidence it works C) Incidental findings. @drjohnm Heart CT calcium score is a great preventive tool helps motivate individuals to work on healthy lifestyle and diet. @drjohnm Heart CT calcium score is a great preventive tool helps motivate individuals to work on healthy lifestyle and diet"
X Link 2025-10-06T20:21Z 68.6K followers, 24.7K engagements

"Agree. Shocking lack of common sense and proportionality Asthma is a serious disease which disproportionately affects the less well off One glance at Flight Radar renders this idea utter nonsense To question even one puff of an inhaler b/c of climate concerns = folly This is what losing the plot in medicine looks like. https://t.co/78ICGCJ4Vo This is what losing the plot in medicine looks like. https://t.co/78ICGCJ4Vo"
X Link 2025-10-07T00:22Z 68.6K followers, 38.1K engagements

"Health care policy is complicated perhaps by design This 👇🏻explains one of the problems w the affordable care act If you know 2+2=4 its hard to comprehend US health policy Its like cars vs cyclists: we get what we tolerate That Americans tolerate this is surprising Ruben May I take a shot at helping you understand You receive donations and have become a spokesperson for Banner Health and the University of Arizona teaching hospital Arizonas largest nonprofit health system. You say youre fighting to make sure insurance premiums Ruben May I take a shot at helping you understand You receive"
X Link 2025-10-07T00:52Z 68.6K followers, [----] engagements

"RT @cardiobrief Candesartan Beats Losartan in Swedish HF Registry: http://wp.me/ppMHd-1UR Uh-oh Candesartan costs more"
X Link 2011-01-11T22:04Z 68.4K followers, [--] engagements

"How about writing a post about med errors and making a mistake on the name of main protagonist. What a dumb mistake. Arrgghh"
X Link 2010-11-13T21:20Z 68.4K followers, [--] engagements

"Dr Anthony Fauci ponders the possibility of an AIDS-free generation w/vaccines playing a sig role. Wow. #progress http://t.co/HCJJmr59Ed http://ow.ly/1ZiDDb http://ow.ly/1ZiDDb"
X Link 2013-07-15T16:43Z 67.2K followers, [--] engagements

"Are you kidding me #aha14 This is no joke http://t.co/OuzIQVRgZZ"
X Link 2014-11-18T00:32Z 68.4K followers, [--] engagements

"In the category of obvious is that (pt-level) clinical trial data should be shared. Agree w/ Dr Drazen of @nejm. http://t.co/8ijDZdCS9U http://www.nejm.org/doi/full/10.1056/NEJMp1415160query=TOC http://www.nejm.org/doi/full/10.1056/NEJMp1415160query=TOC"
X Link 2015-01-15T20:14Z 68.4K followers, [--] engagements

"@cardiobrief @charlesornstein @ethanjweiss 993/1000 pts get the same efficacy/safety. Convenience is a root cause of why #afib increasing"
X Link 2015-01-20T22:43Z 68.4K followers, [--] engagements

"@ethanjweiss @cardiobrief @charlesornstein I consider warfarins variable p-kinectics an advantage: requires engaged and active patient"
X Link 2015-01-20T22:45Z 68.4K followers, [--] engagements

"@ethanjweiss @cardiobrief @charlesornstein You are forcing me to write a post. Five reasons why warfarin is a still a useful drug"
X Link 2015-01-20T22:49Z 68.4K followers, [--] engagements

"@cardiobrief @ethanjweiss @charlesornstein Its ironic that it took experience w/ NOACs to teach us so much about warfarin"
X Link 2015-01-20T22:53Z 68.4K followers, [--] engagements

"@cardiobrief @ethanjweiss @charlesornstein Yes. Me.100%. I would have a home INR monitor a TTR of 99% & bleeding risk sim to asa"
X Link 2015-01-20T22:58Z 68.4K followers, [--] engagements

"@drsuneet @cardiobrief @ethanjweiss @charlesornstein I knew you would say that. That's why I Tweeted you. I'm fair and balanced. @doctorwes"
X Link 2015-01-21T02:23Z 68.4K followers, [--] engagements

"@juliaoftoronto @DrOz @cardiobrief Im no defender but mainstream medicine would not want to tally harms. Egthe field of cardio-oncology"
X Link 2015-04-25T19:45Z 68.4K followers, [--] engagements

"@cardiobrief @juliaoftoronto @DrOz Good pt. Is it wrong to invoke Jesus http://t.co/FpuiZPXaWG Say for perspective on harms http://en.wiktionary.org/wiki/let_him_who_is_without_sin_cast_the_first_stone http://en.wiktionary.org/wiki/let_him_who_is_without_sin_cast_the_first_stone"
X Link 2015-04-25T21:01Z 68.4K followers, [--] engagements

"By many standards the cycling Dutch are happy healthy and smart. Yet their use of #statins is shockingly low http://t.co/oVUwtSnfcK http://www.medscape.com/viewarticle/84533 http://www.medscape.com/viewarticle/84533"
X Link 2015-05-28T14:18Z 68.4K followers, [--] engagements

"A shocker from #EHRA2015: Talk to pts w #afib about lifestyle before ablation. Grin. Preview http://t.co/Rk5PMX8ymJ http://t.co/oIcErFmtWn http://www.medscape.com/viewarticle/846758 http://www.medscape.com/viewarticle/846758"
X Link 2015-06-19T20:59Z 67.1K followers, [--] engagements

"@cardiobrief #COIChat Who is w-out #COI"
X Link 2015-06-22T18:21Z 68.4K followers, [--] engagements

"Letting Coke/Pepsi fund obesity research is like letting Sanofi fund cholesterol Rx Novartis teach CHF classes. Wait. NEJM says its ok"
X Link 2015-08-10T10:43Z 68.4K followers, [--] engagements

"@cardiobrief Agree. But business models share a lot in common: More disease means more units sold. And SSB lead to more disease. #Circle"
X Link 2015-08-10T13:05Z 68.4K followers, [--] engagements

"@EJSMD @fordvox @TomBurtonWSJ All good points. Evidence should be king. Problem is pharma & its KOLs skilled at spinning evidence"
X Link 2015-08-10T15:14Z 68.4K followers, [--] engagements

"Not sure of benefits but its ironic that an oncologist warns us about the side effects of beta-blockers. #Really https://x.com/cardiobrief/status/635674254730752001 Thoughts on this RT @WSJhealth: Heart Drug May Help Cancer Patients http://t.co/EzVqfb9EGR https://x.com/cardiobrief/status/635674254730752001 Thoughts on this RT @WSJhealth: Heart Drug May Help Cancer Patients http://t.co/EzVqfb9EGR"
X Link 2015-08-24T10:11Z 68.4K followers, [--] engagements

"Interesting announcement at first presentation #ESCcongress: NO PICTURES of slides. I wonder why not Its 2015"
X Link 2015-08-29T11:13Z 68.4K followers, [--] engagements

"@EJSMD You keep Tweeting that sort of stuff and @LisaRosenbaum17 might unfollow you. Grin. Grin. Grin"
X Link 2015-09-24T21:24Z 67.1K followers, [--] engagements

"2015 is not [----]. You underestimate the power of #SoMe to change the convo and disrupt the vertical hierarchy of Med https://x.com/cardiobrief/status/662351727245430784 You Dont Know It But The Debate About SPRINT Is AlreadyOver https://t.co/88u7M8cJYp https://x.com/cardiobrief/status/662351727245430784 You Dont Know It But The Debate About SPRINT Is AlreadyOver https://t.co/88u7M8cJYp"
X Link 2015-11-05T19:46Z 68.4K followers, [--] engagements

"@VincentRK @cardiobrief Okmaybe a little hyperbole. I was excited. LAA devices are scary things to unleash into the real world"
X Link 2015-11-11T20:43Z 68.4K followers, [--] engagements

"CMS proposal to severely restrict Watchman is correct. My take on @theheartorg #afib http://www.medscape.com/viewarticle/855441src=rss&utm_source=dlvr.it&utm_medium=twitter http://www.medscape.com/viewarticle/855441src=rss&utm_source=dlvr.it&utm_medium=twitter"
X Link 2015-12-04T16:05Z 68.4K followers, [--] engagements

"Good post Larry. More than ever I believe we need fewer guidelines. Right @vmontori https://x.com/cardiobrief/status/690218621772017664 Why Guidelines Are Bad ForScience https://t.co/oL3SVLQ7hr https://x.com/cardiobrief/status/690218621772017664 Why Guidelines Are Bad ForScience https://t.co/oL3SVLQ7hr"
X Link 2016-01-21T17:15Z 68.4K followers, [--] engagements

"@EJSMD @doctorwes I know. It's not approved for all our pts but if payers cared about care as much as costs they'd pay for this product"
X Link 2016-02-17T20:46Z 68.4K followers, [--] engagements

"@EJSMD @sean_halleran True. That's why I favor crit appraisal & slower adoption of new tech. Like bike racing: fewer mistakes=faster times"
X Link 2016-02-19T16:52Z 68.4K followers, [--] engagements

"@EJSMD @VinayPrasad82 @cardiobrief I try to resist fearing for future generations (its what old people do) but this stuff makes it hard"
X Link 2016-05-26T20:16Z 68.4K followers, [--] engagements

"Reverse COI day: @Wmdillon and I sponsored lunch at @BaptistHealth cath lab. Dont worry we gave fair and balanced coverage to all recent cardio studies. Esp LAAC devices"
X Link 2017-12-21T19:12Z 68.4K followers, [--] engagements

"I have a post brewing on the fake news of obesity paradoxes. Whats holding me up is how best to explain collider stratification bias. Its 10x harder to explain than p values. See this beautiful study https://x.com/venkmurthy/status/982252045208924169 http://jech.bmj.com/content/72/4/302 Do you believe in the #ObesityParadox New analysis of 300k UK adults shows finding of better CVD outcomes in overweight/mild obesity is likely confounding. Linear relationship between CVD incidence & waist circumference/waist-hip ratio/body fat mass. https://t.co/aIAShfuL0g https://t.co/rMRnUbdvKU"
X Link 2018-04-06T19:56Z 68.4K followers, [--] engagements

"Few non-trialists question the actual trial results are results. What we question are a studys biases the validity of results and crucially how it applies to patients. Could non-hobbiest non-anointed less-conflicted docs be the MOST qualified to judge evidence https://x.com/roguerad/status/993173309935247360 @HarryDauerman @SVRaoMD @drjohnm The question which I suspect bothers many trialists is who am I (a non peer reviewed non-trialist) to judge the critique of @drjohnm (another non peer reviewed non-trialist) critique of RCTs https://x.com/roguerad/status/993173309935247360 @HarryDauerman"
X Link 2018-05-06T17:20Z 67.2K followers, [--] engagements

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